Hemodynamic differences in Primary Open Angle and Primary Closed Angle Glaucoma: a cross sectional retrospective study

To determine whether or not there is an association of hemodynamic factors with Primary Closed Angle Glaucoma as well the comparison of these factors in Primary Closed Angle Glaucoma [PCAG] and primary open angle glaucoma [POAG]. A cross sectional retrospective study by medical record review was perused. 170 POAG and 170 PCAG were identified from the record of patients presenting to Christian Eye Hospital, Taxila and different hemodynamic parameters were evaluated. Descriptive statistical analysis as well as logistic regression was performed to analyze the data. High Systolic Perfusion Pressure [SPP], Diastolic Perfusion Pressure [DPP], and Mean Perfusion Pressure [MPP] were more strongly associated with PCAG [p-value 0.0001]and Odd Ratios [OR] 3.65[CI 2.30, 5.78], 7.04[CI 4.22, 11.73] and 6.64[CI 3.31, 14.07] respectively. In patients with no systemic diseases, DPP and Mean Arterial Pressure [MAP] was significantly associated with PCAG [p-value 0.0001] whereas SPP [p-value 0.03] was associated with POAG. We suggest that patients with PCAG have high values of systolic, diastolic and mean perfusion pressure and it can be attributed to disturbance at different levels of visual processing, whereas POAG are associated with low systolic perfusion pressure and high intraocular pressure

Does gender have an effect in the prevalence of types of glaucoma in Pakistani population?

To assess the prevalence of various types of glaucoma, blindness and severity of disease with respect to gender differences. A hospital based retrospective study. Study included 3021 patients presenting to glaucoma clinic. Type and severity of glaucoma in the patients was analyzed to determine the gender inequality. Data was analyzed with the statistical software SPSS. It was found that overall the ratio of males affected with glaucoma was higher then females [2.3: 1]. Males had a more prevalent POAG whereas females were suffering more from PCAG glaucoma. Although the overall prevalence was higher in males but the blindness rate in all types of glaucoma was greater in females. Due to severity in POAG surgery of greater number of females was performed. PEXG and NTG were more pronounced in males. Females have more prevalent PCAG while males have POAG. Overall the blindness rate in different types of glaucoma was high in females therefore the results of present study indicated that gender does have an effect in the prevalence and blindness due to different types of glaucoma